Association Between 5HT1b Receptor Gene and Methamphetamine Dependence
نویسندگان
چکیده
منابع مشابه
Association Between 5HT1b Receptor Gene and Methamphetamine Dependence
Several lines of evidence implicate serotonergic dysfunction in diverse psychiatric disorders including anxiety, depression, and drug abuse. Mice with a knock-out of the 5HT1b receptor gene (HTR1B) displayed increased locomotor response to cocaine and elevated motivation to self-administer cocaine and alcohol. Previous genetic studies showed significant associations of HTR1B with alcohol depend...
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Glutathione S-transferases (GSTs; EC: 2.5.1.18) are ubiquitous multifunctional enzymes, which play a key role in cellular detoxification. Functional genetic polymorphisms in genes encoding GSTM1 (a member of GST class mu; OMIM: 138350), and GSTT1 (a member of GST class theta; OMIM: 600436) have been well defined. The functional null alleles of GSTM1 and GSTT1 represent deletions of GSTM1 and GS...
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ژورنال
عنوان ژورنال: Current Neuropharmacology
سال: 2011
ISSN: 1570-159X
DOI: 10.2174/157015911795017137